DNA Therapies Might Offer Superior Options for Treating Mesothelioma Compared to Radiation Therapy

July 18th, 2009 at 5:38 am (Hall Of Health, House Of Science)

Oncologists and other cancer doctors choose what type of treatment to pursue with each patient. There are many options. There exists no universal treatment course for mesothelioma sufferers. This is because of the relative rareness of the disease, the high mortality rate and low treatment success rate, and the few scientific studies to provide meaningful statistics.

The prospects for mesothelioma patients have been grim, but doctors have recently made progress. Treatments for cancer are traditionally surgery (taking out the tumor and surrounding tissue), chemotherapy (poisoning cancerous cells) and radiation (killing cancer cells with radiation) There are problems with all three. Traditional radiation therapy has not worked well with mesothelioma patients. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

Surgery removes the mesothelial tissue around the tumor. This surgery is extensive and it is not clear how much the patient benefits. Most chemotherapy medication that work on other cancers typically do not work on mesothelioma, and different mixtures of these drugs have not been successful. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.

The high-mortality rate for mesothelioma patients means cutting-edge techniques for cancer are tried out. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. The new drug pemetrexed (brand name Alimta) has shown good results in extending life with mesotheliomas..

Before acting, oncologists review the stage of mesothelioma, position of the tumor, and age and health status of the patient. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Clinical trials using these techniques are being offered to some of those who have mesothelioma.

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